Home » Histamine intolerance and MCAS
Histamine sensitivity and Mast Cell Activation Syndrome (MCAS) are complex and often misunderstood conditions. They are also heavily medicated conditions, and little attention is given to the root cause of the problem focusing on strategies to mitigate symptoms.
Nutrition and gut health can have an impact, as the main enzyme responsible of breaking histamine down (DAO) is produced in the gut, where also most of our immune system resides.
Viral reactivation, genetics, oestrogen fluctuations, stress and many other factors can also contribute to flare ups, and a bespoke and dedicated plan backed by data from functional testing can help tackling the root cause of these conditions.
For those navigating unexplained rashes, gut discomfort, or persistent eczema, it’s possible that histamine intolerance or Mast Cell Activation Syndrome (MCAS) could be at play. These two conditions, often intertwined, highlight the importance of gut health and offer insights into managing symptoms like skin irritation and digestive issues.
What is MCAS and Histamine Intolerance?
Mast Cell Activation Syndrome (MCAS) is a condition where mast cells, a type of immune cell, release too many inflammatory chemicals—including histamine—into the body. This response, meant to protect the body, becomes overactive in MCAS, resulting in a range of symptoms like rashes, itching, digestive problems, and even anxiety. MCAS can be triggered by food, stress, environmental allergens, or other factors, leading to an overabundance of histamine and other inflammatory molecules.
Histamine intolerance, on the other hand, occurs when there’s an imbalance between the amount of histamine released and the body’s ability to break it down. Histamine is a natural substance involved in immune responses and digestion. However, when the body cannot break down excess histamine, symptoms appear. For many, this can result in skin conditions such as eczema or hives, headaches, abdominal cramps, and bloating.
The Role of Gut Health in MCAS and Histamine Intolerance
Your gut is the central hub for balancing histamine. Key enzymes in the digestive tract, specifically Diamine Oxidase (DAO), are responsible for breaking down histamine in the gut. When DAO levels are insufficient, histamine accumulates, which can trigger symptoms associated with histamine intolerance. Factors like poor gut health, infections, inflammation, and nutrient deficiencies (especially in vitamin B6, vitamin C, and copper) can lower DAO levels, making it harder to clear histamine efficiently.
In MCAS, gut health is just as critical because an imbalanced gut can exacerbate immune dysregulation, further fueling symptoms. For example, an unhealthy gut lining may increase inflammation and histamine production, amplifying the effects of both MCAS and histamine intolerance.
Symptoms of MCAS and Histamine Intolerance
Symptoms vary widely but often overlap. Common symptoms include:
These symptoms can become worse after eating high-histamine foods (like aged cheese, alcohol, and fermented foods) or experiencing stress, which both increase histamine levels.
Managing Gut Health for MCAS and Histamine Intolerance
A gut-friendly diet is essential for those with histamine intolerance or MCAS. Strategies for supporting gut health include:
Supplements are another option; some individuals benefit from DAO supplements, which can aid in breaking down dietary histamine. Probiotics are also worth exploring, as they can help maintain a balanced gut microbiome. However, certain strains of bacteria produce histamine, so choosing low-histamine strains is recommended.
Histamine Intolerance
Eczema
Nutritional therapy is the application of nutrition science in the promotion of health, peak performance and individual care. Nutritional therapy practitioners use a wide range of tools to assess and identify potential nutritional imbalances and understand how these may contribute to an individual’s symptoms and health concerns. This approach allows them to work with individuals to address nutritional balance and help support the body towards maintaining health. Nutritional therapy is recognised as a complementary medicine. It is relevant both for individuals looking to enhance their health and wellbeing and for those with chronic conditions wishing to work with or ‘consult’ a nutritional therapist in collaboration with other suitably qualified healthcare professionals. Practitioners consider each individual to be unique and recommend personalised nutrition and lifestyle programmes rather than a ‘one size fits all’ approach. Practitioners never recommend nutritional therapy as a replacement for medical advice and always refer any client with ‘red flag’ signs or symptoms to their medical professional. They will also frequently work alongside a medical professional and will communicate with other healthcare professionals involved in the client’s care to explain any nutritional therapy programme that has been provided.
In the UK, these titles can mean different things — and they’re not all regulated in the same way.
Nutritional therapist: Typically trained to work 1:1 using nutrition and lifestyle to support health and wellbeing, often in a more clinical, root-cause style. Many practitioners choose to be BANT members and CNHC registered, which adds professional standards and accountability.
Nutritionist: The title “nutritionist” isn’t legally protected in the UK so that anyone can use it. However, people on the UK Voluntary Register of Nutritionists (UKVRN) through the Association for Nutrition can use titles such as Registered Nutritionist (RNutr).
Nutrition coach: Often focused on habits, motivation and accountability. “Coach” isn’t a protected title, so training and scope can vary widely.
If you’re choosing someone, check their qualifications, professional registration, and whether their scope aligns with your needs. (For completeness: “dietitian” is a protected title regulated by the HCPC.)
BANT (British Association for Nutrition and Lifestyle Medicine) is a professional organisation for Registered Nutritional Therapy Practitioners and Registered Dietitians which are trained and qualified in clinical practice to meet national standards and work in a one-to-one setting.
BANT practitioner members are required to be registered either with Complementary and Natural Healthcare Council (CNHC) or be statutorily regulated. CNHC holds a register accredited by the Professional Standards Authority for Health and Social Care (PSA), an independent body accountable to the UK Parliament. BANT members are also required to meet Continuing Professional Development (CPD) standards.
Being a BANT member highlights the high standard of my training and work practice, reassuring clients of the quality of the consultations and plans I provide at Food Power Nutrition.
It varies. Some people notice changes within a few weeks after implementing the key recommendations, while deeper, longer-term issues can take longer to shift. Your timeline depends on your starting point, what we’re addressing, and how consistently you can follow the plan.
My focus is sustainable, long-term improvement — not quick fixes — and we’ll agree on realistic expectations as part of your assessment.
You can contact me by email at lucia@foodpowernutrition.com or via the Practice Better chat for support between sessions.
I aim to reply within one working day. Please note my working hours are 9 am–6 pm, Monday to Friday, so messages sent outside these times may be answered the next working day.
No. I offer online consultations via Practice Better (telehealth/Zoom), which you can access through your client portal.
In-person initial consultations are available on Wednesday afternoons at Angel Gyms, 48 Provost St, London N1 7SU. All follow-up sessions are held online.
You can expect a personalised, practical plan tailored to your symptoms, history, and goals, with clear priorities and measurable steps. Results vary from person to person, but progress is most substantial when you implement the recommendations consistently, attend follow-up sessions where relevant, and use supplements/testing only where appropriate.
We’ll discuss realistic expectations and goals during your discovery call so you know exactly what we’re aiming for and how we’ll measure progress.
If you’d like to talk it through first, you can book a free discovery call to discuss your health concerns, the most suitable service, and costs. Please feel free to ask for information via the contact form, specifying if you wish to be contacted via email or via phone. I am happy to offer a free discovery call to discuss your current health concerns and explore how we can work together.
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Starting your route back to health can be daunting. Arrange a call with no obligation and I will discuss your issue and how I can help.
In person appointments:
Every Wednesday Afternoon
CENTRAL LONDON CLINIC:
Angel Gyms,
48 Provost St,
Shoreditch,
London N1 7SU
Nourishing recipes created by a nutritional therapist. Full of delicious, seasonal, balanced and easy to make meals. Register now to download your free copy.
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